Bioequivalence and Bioavailability Forum • scABE and missings

scABE and missings [🇷 for BE/BA]

posted by d_labes – Berlin, Germany, 2011-01-21 17:19 (5224 d 13:23 ago) – Posting: # 6478
Views: 30,459

Hi ElMaestro

❝ Correction: Sorry, I meant something else than I initially wrote. It is missing values that is the concern issue because of the difference between a normal linear model and the reml approach by a mixed model.

Good question! Next question please :-D

.

To be honest: Don't know exactly. In the Progesterone guidance it is written "... Further assume that there are no missing observations ...". But only under the Heading "Example SAS Codes: fully replicated 4-way design".

My observation is that this guidance is in some instances rather vague or gives no sufficient explanation why what is done that way. Just to name "the unknown x = estimate² - stderr²" or "use GLM for partial replicate and MIXED for full replicate".

—
Regards,

Detlew

Complete thread:

Feature suggestion for bear and PowerTOST ElMaestro 2011-01-16 19:13 [🇷 for BE/BA]
- Sample size for widened scaled ABE limits d_labes 2011-01-17 13:19
  - 0.760 or... Helmut 2011-01-17 14:38
    - ... full precision is the question d_labes 2011-01-17 16:37
      - ... full precision is the question Helmut 2011-01-17 18:06
        
        OT: Number of horns on a unicorn d_labes 2011-01-18 08:32
        
        Goooogle Helmut 2011-01-18 11:44
  - Cadmium ElMaestro 2011-01-19 17:50
    - Never eaten Cadmium deliberately d_labes 2011-01-20 15:00
      - Never eaten Cadmium deliberately Helmut 2011-01-20 15:25
        
        Call of duty for simulants d_labes 2011-01-20 16:15
        
        Counterinuitive Helmut 2011-01-21 04:13
        
        Counterintuitive d_labes 2011-01-21 08:36
        
        Counterintuitive Helmut 2011-01-21 12:53
        
        Counterinuitive, but ... d_labes 2011-01-21 12:12
        
        Counterinuitive, but ... Helmut 2011-01-21 13:01
        
        Wow, Wow ... d_labes 2011-01-21 14:43
        
        Never eaten Cadmium deliberately ElMaestro 2011-01-21 12:59
        
        Simulants of the world, unite! Helmut 2011-01-21 14:05
        
        Simulants of the world, unite! ElMaestro 2011-01-21 14:52
        
        Hyslop, Howe, scaled ABE and that all d_labes 2011-01-21 15:28
        
        Hyslop, Howe, scaled ABE and that all ElMaestro 2011-01-21 15:45
        
        scABE and missingsd_labes 2011-01-21 16:19
        
        Intuition Helmut 2011-01-21 18:41
      - Never eaten Cadmium deliberately ElMaestro 2011-01-20 15:34
        
        Use of Cadmium d_labes 2011-01-20 16:06
        
        Use of Cadmium ElMaestro 2011-01-20 16:52
        Use of Cadmium ElMaestro 2011-01-20 17:53