Bioequivalence and Bioavailability Forum • Use of Cadmium

Use of Cadmium [🇷 for BE/BA]

posted by ElMaestro – Denmark, 2011-01-20 18:53 (5626 d 11:09 ago) – Posting: # 6462
Views: 34,824

OK, here what I meant with my last posts and the gibberish code.

[image]

We have for instance 24 patients in a 2,2,3-BE trial, expected T/R being 1.0 and expected CV is 30%. This gives us a power of 0.87. Scaling preserves power. Thus should the variability be 50% and with preserved power we have 0.6983 as our lower acceptance range and 1.4320 as the upper. Wunderbar. This is the blue line, or shall we call it the EMA line.

I propose to check how the behavior is once the expected R/T diviates from 1.0 and being 0.95 (red), 0.90 (yellow) and 0.85 (green); these curves preserve the power within themselves but of course not between them. It was intended as a graphical illustration of the limitation of the EMA approximation when T/R differs from 1.0.

Note: We are now no longer so intimately connected with the original thread topic.

—
Pass or fail!
ElMaestro

Complete thread:

Feature suggestion for bear and PowerTOST ElMaestro 2011-01-16 19:13 [🇷 for BE/BA]
- Sample size for widened scaled ABE limits d_labes 2011-01-17 13:19
  - 0.760 or... Helmut 2011-01-17 14:38
    - ... full precision is the question d_labes 2011-01-17 16:37
      - ... full precision is the question Helmut 2011-01-17 18:06
        
        OT: Number of horns on a unicorn d_labes 2011-01-18 08:32
        
        Goooogle Helmut 2011-01-18 11:44
  - Cadmium ElMaestro 2011-01-19 17:50
    - Never eaten Cadmium deliberately d_labes 2011-01-20 15:00
      - Never eaten Cadmium deliberately Helmut 2011-01-20 15:25
        
        Call of duty for simulants d_labes 2011-01-20 16:15
        
        Counterinuitive Helmut 2011-01-21 04:13
        
        Counterintuitive d_labes 2011-01-21 08:36
        
        Counterintuitive Helmut 2011-01-21 12:53
        
        Counterinuitive, but ... d_labes 2011-01-21 12:12
        
        Counterinuitive, but ... Helmut 2011-01-21 13:01
        
        Wow, Wow ... d_labes 2011-01-21 14:43
        
        Never eaten Cadmium deliberately ElMaestro 2011-01-21 12:59
        
        Simulants of the world, unite! Helmut 2011-01-21 14:05
        
        Simulants of the world, unite! ElMaestro 2011-01-21 14:52
        
        Hyslop, Howe, scaled ABE and that all d_labes 2011-01-21 15:28
        
        Hyslop, Howe, scaled ABE and that all ElMaestro 2011-01-21 15:45
        
        scABE and missings d_labes 2011-01-21 16:19
        
        Intuition Helmut 2011-01-21 18:41
      - Never eaten Cadmium deliberately ElMaestro 2011-01-20 15:34
        
        Use of Cadmium d_labes 2011-01-20 16:06
        
        Use of Cadmium ElMaestro 2011-01-20 16:52
        Use of CadmiumElMaestro 2011-01-20 17:53