steady state in WinNonlin (example) [Software]

posted by pkpdpkpd – 2007-04-05 18:33 (6023 d 22:18 ago) – Posting: # 633
Views: 16,189

Dear Helmut!

Thanks for your instructions. However, I have two problems:
  1. The version 5.01 of WinNonLin that I have do not have "Linear" function in the PK/PD/NCA Wizard.
  2. The approach I would like to use for the assessment of steady state is repeated measures ANOVA of log concentrations instead of linear regression you are describing, since I am comparing the pre-dose concentrations in several subjects on three consecutive days.
If I have one dependent variable (concentration) and subject as a random effect (??), and day as a fixed effect (???), how can I use Lin Mix to do the calculations.


PS. In the linear regression while assessing the slope, should it be 95% or 90% CI?

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