Bioequivalence and Bioavailability Forum • steady state in WinNonlin (example)

steady state in WinNonlin (example) [Software]

posted by pkpdpkpd – 2007-04-05 18:33 (6023 d 22:18 ago) – Posting: # 633
Views: 16,189

Dear Helmut!

Thanks for your instructions. However, I have two problems:

The version 5.01 of WinNonLin that I have do not have "Linear" function in the PK/PD/NCA Wizard.
The approach I would like to use for the assessment of steady state is repeated measures ANOVA of log concentrations instead of linear regression you are describing, since I am comparing the pre-dose concentrations in several subjects on three consecutive days.

If I have one dependent variable (concentration) and subject as a random effect (??), and day as a fixed effect (???), how can I use Lin Mix to do the calculations.

PKPDPKPD

PS. In the linear regression while assessing the slope, should it be 95% or 90% CI?

Complete thread:

assessment of steady state in WinNonLin pkpdpkpd 2007-04-04 22:52 [Software]
- steady state in WinNonlin (example) Helmut 2007-04-05 02:30
  - steady state in WinNonlin (example)pkpdpkpd 2007-04-05 16:33
    - steady state in WinNonlin (example) Helmut 2007-04-05 17:16
      - steady state in WinNonlin (example) pkpdpkpd 2007-04-05 17:39
        
        steady state in WinNonlin… Helmut 2007-04-05 18:40
        
        steady state in WinNonlin… pkpdpkpd 2007-04-05 21:37
        Paired Design in WinNonlin Helmut 2007-04-06 00:23
  - steady state in WinNonlin (example) apapanas 2018-01-03 14:44
    - steady state in WinNonlin (example) Helmut 2018-01-04 17:11
      - qt in WinNonlin mittyri 2018-01-04 23:13
        
        ‘Deep’ bug Helmut 2018-01-05 00:37
        Workarounds for v6.3+ Helmut 2018-01-08 00:40
        
        Workarounds for v6.3+ apapanas 2018-01-10 12:47