PK PD modelling [Tips / Tricks]

posted by luvblooms4u – 2010-11-12 07:31 (4886 d 06:03 ago) – Posting: # 6140
Views: 17,161

Dear HS

❝ I’m afraid you have to give us more informations. Normally the half-life of drugs is too short to be influenced by an increasing number of cells (are you thinking about a tumor?).


Yes mainly for Tumor cell related metabolism!! and also for the drugs that get distributed in tissues for longer period of time.

❝ Exceptions are drugs with very long half-lives (let’s say, more than a week), or the patient is in true steady-state (again, I’m talking about weeks).


Yes! That is the main area of concern

❝ Some general remarks about modeling:

Get some books. Read them. Take a vacation. Read them again.


:-D. I will love to do that!

If you really notice a change in clearance (e.g., in a multiple dose

  study trough values increase to a pseudo-equilibrium and subsequently

  decrease to the final steady state), try the following methods to model

  the changing clearance:

  Add a lag-time.


Let me try this !!

  Try a catenary model (additional hypothetical compartment before

    the central).


Yeah This might be the approach I should look for but what if I want to see and related the metabolism in the hypothetical compartment ;-)


Thanks for your suggestion!!
Let me read them first and clear my thoughts then I will be back!

Thanks a lot

Luv!!

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