PK PD modelling [Tips / Tricks]
❝ I’m afraid you have to give us more informations. Normally the half-life of drugs is too short to be influenced by an increasing number of cells (are you thinking about a tumor?).
Yes mainly for Tumor cell related metabolism!! and also for the drugs that get distributed in tissues for longer period of time.
❝ Exceptions are drugs with very long half-lives (let’s say, more than a week), or the patient is in true steady-state (again, I’m talking about weeks).
Yes! That is the main area of concern
❝ Some general remarks about modeling:
❝ • Get some books. Read them. Take a vacation. Read them again.
. I will love to do that!
❝ • If you really notice a change in clearance (e.g., in a multiple dose
❝
study trough values increase to a pseudo-equilibrium and subsequently
❝
decrease to the final steady state), try the following methods to model
❝
the changing clearance:
❝
• Add a lag-time.
Let me try this !!
❝
• Try a catenary model (additional hypothetical compartment before
❝
the central).
Yeah This might be the approach I should look for but what if I want to see and related the metabolism in the hypothetical compartment
Thanks for your suggestion!!
Let me read them first and clear my thoughts then I will be back!
Thanks a lot
Luv!!
Complete thread:
- PK PD modelling luvblooms4u 2010-11-09 07:07
- time-dependent clearance yjlee168 2010-11-09 20:16
- PK/PD + PopPK software Helmut 2010-11-10 03:03
- PK/PD + PopPK software yjlee168 2010-11-10 11:41
- time-dependent clearance luvblooms4u 2010-11-12 05:29
- time-dependent clearance SDavis 2010-11-16 23:19
- PK/PD + PopPK software Helmut 2010-11-10 03:03
- PK PD modelling Helmut 2010-11-10 04:36
- PK PD modellingluvblooms4u 2010-11-12 06:31
- Profile check first! Helmut 2010-11-13 15:47
- PK PD modellingluvblooms4u 2010-11-12 06:31
- time-dependent clearance yjlee168 2010-11-09 20:16