Blind ? [Two-Stage / GS Designs]
Dear Ohlbe,
using a blinded method means that the statistical method used does not use information on treatment groups (even if it may be available). As a simplified example the method can used the mean across group, but not the means within group.
The reason for using such a method has only to do with the formal test decision and therefore the type-I-error. This is in contrast to "traditional" trials were blinding (meaning noone or as few people as possible know which subject receives which treatment) is used to ensure that no bias arises from knowing the treatment. No attempt to prevent bias is made here (since people involved know the treatment).
using a blinded method means that the statistical method used does not use information on treatment groups (even if it may be available). As a simplified example the method can used the mean across group, but not the means within group.
The reason for using such a method has only to do with the formal test decision and therefore the type-I-error. This is in contrast to "traditional" trials were blinding (meaning noone or as few people as possible know which subject receives which treatment) is used to ensure that no bias arises from knowing the treatment. No attempt to prevent bias is made here (since people involved know the treatment).
Complete thread:
- 2-stage design with interim sample size estimation d_labes 2010-10-05 15:09 [Two-Stage / GS Designs]
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
- Null = bioINequivalence Helmut 2010-10-25 19:16
- 2-stage design with interim sample size estimation d_labes 2010-10-26 13:28
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind ? Ohlbe 2010-10-27 23:37
- Blind ?Jack 2010-10-28 10:24
- Blind 2Stage Astea 2019-05-30 10:37
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Which elephant? Helmut 2019-06-02 20:14
- Blind interim in parallel design? Astea 2019-06-03 01:47
- Blind men d_labes 2019-06-05 12:23
- The Blind Leading the Blind Astea 2019-06-06 00:55
- Blind men d_labes 2019-06-05 12:23
- Blind interim in parallel design? Astea 2019-06-03 01:47
- Which elephant? Helmut 2019-06-02 20:14
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage Astea 2019-05-30 10:37
- Blind ?Jack 2010-10-28 10:24
- Blind ? Ohlbe 2010-10-27 23:37
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20