Blind ? [Two-Stage / GS Designs]

posted by Jack Homepage – Lancaster, United Kingdom, 2010-10-28 10:24 (3567 d 04:22 ago) – Posting: # 6095
Views: 10,347

Dear Ohlbe,

using a blinded method means that the statistical method used does not use information on treatment groups (even if it may be available). As a simplified example the method can used the mean across group, but not the means within group.

The reason for using such a method has only to do with the formal test decision and therefore the type-I-error. This is in contrast to "traditional" trials were blinding (meaning noone or as few people as possible know which subject receives which treatment) is used to ensure that no bias arises from knowing the treatment. No attempt to prevent bias is made here (since people involved know the treatment).

Complete thread:

 Admin contact
20,963 posts in 4,373 threads, 1,459 registered users;
online 16 (0 registered, 16 guests [including 6 identified bots]).
Forum time: Monday 14:47 CEST (Europe/Vienna)

Garbage in, garbage out.
It’s very very simple.    Anders Fuglsang

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz