Blind ? [Two-Stage / GS Designs]
Dear Jack,
What's probably confusing to a number of people following this thread is what you exactly mean with "blind". In clinical trials this is usually meant as not knowing which treatment is administered to which patient/subject. In a BE trial this usually only applies to the bioanalytical lab. You can't run the statistical analysis without unblinding (even if you call the products A and B and don't tell the statistician which is the test and which is the reference, it won't make any difference).
So to keep it short, a question from a non-statistician: what do you exactly mean by blinded in this particular context ? Blinded to what ?
Regards
Ohlbe
What's probably confusing to a number of people following this thread is what you exactly mean with "blind". In clinical trials this is usually meant as not knowing which treatment is administered to which patient/subject. In a BE trial this usually only applies to the bioanalytical lab. You can't run the statistical analysis without unblinding (even if you call the products A and B and don't tell the statistician which is the test and which is the reference, it won't make any difference).
So to keep it short, a question from a non-statistician: what do you exactly mean by blinded in this particular context ? Blinded to what ?
Regards
Ohlbe
—
Regards
Ohlbe
Regards
Ohlbe
Complete thread:
- 2-stage design with interim sample size estimation d_labes 2010-10-05 15:09 [Two-Stage / GS Designs]
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
- Null = bioINequivalence Helmut 2010-10-25 19:16
- 2-stage design with interim sample size estimation d_labes 2010-10-26 13:28
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind ?Ohlbe 2010-10-27 23:37
- Blind ? Jack 2010-10-28 10:24
- Blind 2Stage Astea 2019-05-30 10:37
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Which elephant? Helmut 2019-06-02 20:14
- Blind interim in parallel design? Astea 2019-06-03 01:47
- Blind men d_labes 2019-06-05 12:23
- The Blind Leading the Blind Astea 2019-06-06 00:55
- Blind men d_labes 2019-06-05 12:23
- Blind interim in parallel design? Astea 2019-06-03 01:47
- Which elephant? Helmut 2019-06-02 20:14
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage Astea 2019-05-30 10:37
- Blind ? Jack 2010-10-28 10:24
- Blind ?Ohlbe 2010-10-27 23:37
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20