Null = bioINequivalence [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2010-10-25 21:16 (4893 d 06:56 ago) – Posting: # 6078
Views: 13,644

Dear Jack!

❝ this is quite a complex question…


True.

❝ … to which I will add some more questions.


:-D

Well, I think the applicability of commonly used methods is questionable, because of the different way the Null is formulated in BE studies.

Just a quote from Potvin et al.,* after referring different approaches:

Regardless, none of the methods are validated for crossover studies and two one-sided t-tests, so there is a need to start from the beginning in considering these approaches.




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