Null = bioINequivalence [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2010-10-25 19:16 (3573 d 22:36 ago) – Posting: # 6078
Views: 10,677

Dear Jack!

» this is quite a complex question…


» … to which I will add some more questions.


Well, I think the applicability of commonly used methods is questionable, because of the different way the Null is formulated in BE studies.

Just a quote from Potvin et al.,* after referring different approaches:

Regardless, none of the methods are validated for crossover studies and two one-sided t-tests, so there is a need to start from the beginning in considering these approaches.

Dif-tor heh smusma 🖖
Helmut Schütz

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