Null = bioINequivalence [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2010-10-25 19:16  – Posting: # 6078
Views: 9,635

Dear Jack!

» this is quite a complex question…


» … to which I will add some more questions.


Well, I think the applicability of commonly used methods is questionable, because of the different way the Null is formulated in BE studies.

Just a quote from Potvin et al.,* after referring different approaches:

Regardless, none of the methods are validated for crossover studies and two one-sided t-tests, so there is a need to start from the beginning in considering these approaches.

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
20,242 posts in 4,259 threads, 1,397 registered users;
online 5 (0 registered, 5 guests [including 2 identified bots]).
Forum time (Europe/Vienna): 04:05 CET

Operational hectic replaces
intellectual calms.    Alexander Huiskes

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz