Null = bioINequivalence [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2010-10-25 17:16  – Posting: # 6078
Views: 10,511

Dear Jack!

» this is quite a complex question…


» … to which I will add some more questions.


Well, I think the applicability of commonly used methods is questionable, because of the different way the Null is formulated in BE studies.

Just a quote from Potvin et al.,* after referring different approaches:

Regardless, none of the methods are validated for crossover studies and two one-sided t-tests, so there is a need to start from the beginning in considering these approaches.

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
20,801 posts in 4,354 threads, 1,446 registered users;
online 4 (0 registered, 4 guests [including 3 identified bots]).
Forum time: 02:14 UTC (Europe/Vienna)

Medical statistician: One who will not accept that Columbus discovered America…
because he said he was looking for India in the trial plan.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz