WNL almost the same as SAS [Software]

posted by Maura – 2010-09-03 16:07 (5358 d 07:52 ago) – Posting: # 5883
Views: 5,802

Dear all,

First I am very thank you for help!!
Where did I get the coding of carryover from? This was removed from the forum itself. I found the encoding of an example of a book (C5300.zip):

/***SAS code for examples in Chapter 4 of                              ***/
/*** Bioequivalence and Statistics in Clinical Pharmacology,           ***/
/*** by Scott Patterson and Byron Jones,***/
/*** Chapman and Hall/CRC Press: Boca Raton, London and New York, 2005


In example 4.5 the data is arranged in the same way. I create the column “Carry” based on this example.

Those results from WNL was a friend who showed me, because I don't have the software. The results achieved through the SAS I get well.
I am very happy to have achieved these results with the help of you, but what I really need is to estimate the effect of "carryover" with one degree of freedom (ANOVA in Chow & Liu page 366 - second edition), when this same model is used to drug interaction (with x alone), and so I would not know how to create the column "Carry".
Recalling that in Brazil, ANVISA is criticizing this design, so we are trying to estimate the carryover effect and determining its significance, trying to justify the design. ANVISA wants it done a study for bioequivalence between "A + I" and "A" and another for "A + I" and "I".
Does anyone know how to do this parameterization??!

Thank you all.


Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

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