SE: SAS / PHX-WNL / manual [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2010-08-19 14:36 (5372 d 17:26 ago) – Posting: # 5809
Views: 9,337

Dear Bharat,

please add a column with the subject's ID. Edit your original post instead of posting a new one. THX.

❝ Please clarify me that a balanced design is nothing but number of sub facing TR is equal to number of sub facing RT right?


Yes.

❝ what is the formula for calculation of standard error of difference?


SE(T-R)=sqrt[2×MSEresidual/(n1+n2)], where n1 and n2 are the numbers of subjects in sequences 1 and 2.


Edit: I played around with your dataset. I coded the subjects ID to 1-9, 1-9, 10-16, 10-16. I don't have SAS, but in Phoenix/WinNonlin v6.1 I could confirm SAS's results, both for AUCt and AUCinf.
Interestingly I got for SE(T-R):
          PHX     'manual'
AUC  0.0381181 0.0378191
AUCinf  0.0378947 0.0375974

Can one of our SAS-owners please check these results? Maybe my formula is wrong.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,669 registered users;
55 visitors (0 registered, 55 guests [including 5 identified bots]).
Forum time: 08:02 CEST (Europe/Vienna)

My doctor gave me six months to live,
but when I couldn’t pay the bill
he gave me six months more.    Walter Matthau

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5