Bioequivalence and Bioavailability Forum • clopidogrel

clopidogrel [Bioanalytics]

posted by Dr_Dan – Germany, 2010-08-11 11:24 (5780 d 14:50 ago) – Posting: # 5768
Views: 9,495

Dear Ioanam
No, you are not wrong! In my last Clopidogrel study (75 mg single dose replicate design) I had several subjects showing great differences between treatments.
One subject under reference: first treatment 2963 pg/ml, second treatment: 399 pg/ml → factor >7. Onother subject also under reference: first treatment 354 pg/ml, second treatment: 9227 pg/ml → factor 30! (o.k. this was the most extreme…)
Clopidogrel is a lausy variable drug.
Kind regards
Dan

—
Kind regards and have a nice day
Dr_Dan

Complete thread:

clopidogrel ioanam 2010-08-10 10:42 [Bioanalytics]
- clopidogrel Dr_Dan 2010-08-10 11:21
  - clopidogrel ioanam 2010-08-10 11:28
  - clopidogrel ioanam 2010-08-10 11:43
    - clopidogrel Ohlbe 2010-08-10 12:17
- clopidogrel ioanam 2010-08-10 14:13
  - clopidogrel Ohlbe 2010-08-10 14:59
    - clopidogrel ioanam 2010-08-10 15:17
      - clopidogrel Ohlbe 2010-08-10 16:12
        
        clopidogrel ioanam 2010-08-10 18:34
        
        clopidogrelDr_Dan 2010-08-11 09:24
        
        clopidogrel ioanam 2010-08-11 11:08
        
        clopidogrel Ohlbe 2010-10-05 00:06