Bioequivalence and Bioavailability Forum • clopidogrel

clopidogrel [Bioanalytics]

posted by ioanam – Romania, 2010-08-10 20:34 (5781 d 05:39 ago) – Posting: # 5767
Views: 9,502

Dear Ohlbe
we have results from 63 subjects; the dose administered was 150 mg.

Thank you for the EPARs. I already compared our results with those reported there.
But I have other reports from other studies using the same dose (150 mg) and the results were lower than ours (in general around 2 - 3 ng/ml).

In this study, the between - subject variability is around 50% (?).

Even clopidogrel is a HVD, can I have such differences in the same subjects, eq:
- almost 6 ng/ml (for one formulation) compared to 15 ng/ml (the other formulation)
- almost 6 ng/ml compared to almost 19 ng/ml
or
- almost 3 ng/ml compared to almost 18 ng/ml?

These differences seems to be to high (for me). Perhaps I am wrong. I don't know.

Regards,
ioanam

Complete thread:

clopidogrel ioanam 2010-08-10 10:42 [Bioanalytics]
- clopidogrel Dr_Dan 2010-08-10 11:21
  - clopidogrel ioanam 2010-08-10 11:28
  - clopidogrel ioanam 2010-08-10 11:43
    - clopidogrel Ohlbe 2010-08-10 12:17
- clopidogrel ioanam 2010-08-10 14:13
  - clopidogrel Ohlbe 2010-08-10 14:59
    - clopidogrel ioanam 2010-08-10 15:17
      - clopidogrel Ohlbe 2010-08-10 16:12
        
        clopidogrelioanam 2010-08-10 18:34
        
        clopidogrel Dr_Dan 2010-08-11 09:24
        
        clopidogrel ioanam 2010-08-11 11:08
        
        clopidogrel Ohlbe 2010-10-05 00:06