Bioequivalence and Bioavailability Forum • meta analysis?

meta analysis? [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2010-08-06 20:31 (5005 d 15:29 ago) – Posting: # 5735
Views: 15,667

Dear ElMaestro!

❝ I am afraid I do not have a qualified opinion.

Me not either, but I’m a little bit concerned about the (lacking) α-spending in meta analysis.

❝ Do you have a good idea about m.a.? I'd be happy to hear.

See Chapter 16 in Chow & Liu (3^rd ed. 2009). They refer to two models (based on 2×2 cross-over studies only), where the first one is rather restrictive – assuming equal CV_intra and CV_inter across studies. Personal experience: nil.

Chow S-C, Liu J-p. Meta-analysis for bioequivalence review.
J Biopharm Stat. 1997:7(1):97–111. doi:10.1080/10543409708835172
Chow S-C, J Shao J. Bioequivalence review for drug interchangeability.
J Biopharm Stat. 1999;9(3):485–97. doi:10.1081/BIP-100101189

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

inter-batch variability? Dr_Dan 2010-08-04 10:29 [Regulatives / Guidelines]
- inter-batch variability? Pavidus 2010-08-04 11:57
- inter-batch variability? d_labes 2010-08-04 13:58
- inter-batch variability? ElMaestro 2010-08-04 17:09
  - Between study variability common for HVDs Helmut 2010-08-04 19:45
    - Between study variability common for HVDs ElMaestro 2010-08-04 21:01
      - Representative batches? Helmut 2010-08-04 23:42
        
        Representative batches? ElMaestro 2010-08-05 08:40
        
        Representative batches? Helmut 2010-08-05 12:30
        
        Representative batches? Dr_Dan 2010-08-05 08:58
        
        Representative batches? Helmut 2010-08-05 12:45
        
        Confidence intervals vs. point estimators Dr_Dan 2010-08-06 09:55
        
        Confidence intervals vs. point estimators ElMaestro 2010-08-06 12:34
        
        Confidence intervals vs. point estimates Helmut 2010-08-06 13:20
        Confidence intervals vs. point estimators Dr_Dan 2010-08-06 14:44
        
        Confidence intervals vs. point estimators ElMaestro 2010-08-06 15:01
        
        meta analysis? martin 2010-08-06 17:25
        
        meta analysis? ElMaestro 2010-08-06 17:57
        
        meta analysis?Helmut 2010-08-06 18:31
        
        meta analysis? Ohlbe 2010-08-06 23:21
        
        No chance against RMS? Dr_Dan 2010-08-10 12:27
        
        No chance against RMS? ElMaestro 2010-08-10 16:26
  - Batch-to-Batch Pharmacokinetic Variability kumarnaidu 2016-07-20 07:16
    - tlast (Common) Helmut 2016-07-20 10:48
      - tlast (Common) nobody 2019-02-21 15:20
        
        tlast (Common) ElMaestro 2019-02-21 16:32
        
        tlast (Common) nobody 2019-02-21 17:02
        
        tlast (Common) ElMaestro 2019-02-21 18:02
        
        tlast (Common) nobody 2019-02-21 18:17