meta analysis? [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2010-08-06 20:31 (4801 d 23:27 ago) – Posting: # 5735
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Dear ElMaestro!

❝ I am afraid I do not have a qualified opinion.

Me not either, but I’m a little bit concerned about the (lacking) α-spending in meta analysis.

❝ Do you have a good idea about m.a.? I'd be happy to hear.

See Chapter 16 in Chow & Liu (3rd ed. 2009). They refer to two models (based on 2×2 cross-over studies only), where the first one is rather restrictive – assuming equal CVintra and CVinter across studies. Personal experience: nil.

  1. Chow S-C, Liu J-p. Meta-analysis for bioequivalence review.
    J Biopharm Stat. 1997:7(1):97–111. doi:10.1080/10543409708835172
  2. Chow S-C, J Shao J. Bioequivalence review for drug interchangeability.
    J Biopharm Stat. 1999;9(3):485–97. doi:10.1081/BIP-100101189

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