Bioequivalence and Bioavailability Forum • meta analysis?

meta analysis? [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2010-08-06 20:31 (5403 d 20:51 ago) – Posting: # 5735
Views: 17,750

Dear ElMaestro!

❝ I am afraid I do not have a qualified opinion.

Me not either, but I’m a little bit concerned about the (lacking) α-spending in meta analysis.

❝ Do you have a good idea about m.a.? I'd be happy to hear.

See Chapter 16 in Chow & Liu (3^rd ed. 2009). They refer to two models (based on 2×2 cross-over studies only), where the first one is rather restrictive – assuming equal CV_intra and CV_inter across studies. Personal experience: nil.

Chow S-C, Liu J-p. Meta-analysis for bioequivalence review.
J Biopharm Stat. 1997:7(1):97–111. doi:10.1080/10543409708835172
Chow S-C, J Shao J. Bioequivalence review for drug interchangeability.
J Biopharm Stat. 1999;9(3):485–97. doi:10.1081/BIP-100101189

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Helmut Schütz

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