Bioequivalence and Bioavailability Forum

To Err is Human [General Statistics]

posted by preyes323 – 2010-07-17 13:14 (5812 d 19:27 ago) – Posting: # 5648
Views: 16,341

Hi d_labes,

❝ I have calculated using (is theta in your code)

❝ theta² = ((log(1.25)/0.2936)²=(0.76)²

❝ (BTW: Yes nitpickers, of course I know it's really

❝ (log(1.25)/sqrt(log(0.3*0.3+1)))^2=(0.7601283...)^2 :cool: .)

Yes, I included theta in my code. From what I see our main difference might be in the formula for the crit bound. The formula I used is the one from the FDA progesterone guideline. Did you use the same?

data SABE.upper_cmax;

   merge SABE.dglm1_cmax SABE.iglm2_cmax;

   theta=((log(1.25))/0.25)**2;

   y=-theta*s2wr;

   boundy=y*dfd/cinv(0.95,dfd);

   sWR=sqrt(s2wr);

   critbound=(x+y)+sqrt(((boundx-x)**2)+((boundy-y)**2));

run;

❝ Dear Paolo: Sorry but this question is plaguing us as well and is source of our continuing discussion here.

❝ Especially we don't know if one can trust in the results of the FDA Proc Mixed code in case of the extra-reference design your data came from. :ponder:

I see.

Thanks and Regards,
Paolo

Complete thread:

SABE Reference Variability and CI Computation preyes323 2010-07-12 17:12 [General Statistics]
- Dataset Helmut 2010-07-12 17:26
  - Dataset preyes323 2010-07-12 18:20
    - Data format Helmut 2010-07-12 18:38
      - Data format preyes323 2010-07-13 01:16
        
        SAS and/or Phoenix/WinNonlin-experts around? Helmut 2010-07-13 02:29
        
        Phoenix/WinNonlin-experts around? d_labes 2010-07-13 12:15
        
        Phoenix/WinNonlin-experts around? Helmut 2010-07-13 13:42
        
        Mixed interest d_labes 2010-07-13 15:11
        
        Mixed interest Helmut 2010-07-13 19:19
        
        lme() answer and beyond ... d_labes 2010-07-14 10:41
        
        lme() answer and beyond ... Helmut 2010-07-14 13:47
        
        AIC, BIC and that all ... d_labes 2010-07-15 12:01
        
        To Err is Human d_labes 2010-07-13 11:51
        
        To Err is Human, but... Helmut 2010-07-13 13:45
        
        ... to Arr is Pirate d_labes 2010-07-13 15:47
        
        Brilliant page!!! ElMaestro 2010-07-14 21:03
        
        To Err is Human preyes323 2010-07-14 14:45
        
        Heads up! Helmut 2010-07-14 15:17
        To Err is Teacher d_labes 2010-07-15 11:05
        
        To Err is Human preyes323 2010-07-16 02:28
        
        To Err is Human d_labes 2010-07-16 10:42
        
        To Err is Humanpreyes323 2010-07-17 11:14
        
        Regulatory constants d_labes 2010-07-19 10:00
        
        Data format ElMaestro 2011-02-06 11:54
        
        SAS System Viewer Helmut 2011-02-06 13:02

To Err is Human [General Sta­tis­tics]

Complete thread:

To Err is Human [General Statistics]