CI for Transformed data Unbalanced study [General Sta­tis­tics]

Dear HS,

» I guess that’s not your real name

» Let’s call Xt the LSM of the test, and Xr the LSM of the reference (log-scale).

Can you help me with the formula for LSM (I wish to do a manual calculation, for verification purposes) and a brief explaination about why this method is used for unbalanced study?

Thanks a million for the other formula and the references.

Truly,
USFDA_EMEA