Bioequivalence and Bioavailability Forum

Outlier tests (EMA & Canada) [Outliers]

posted by Helmut  – Vienna, Austria, 2010-06-15 14:56 (5502 d 09:35 ago) – Posting: # 5515
Views: 19,928

Dear Dan & all!

❝ […] Lorelei Lutter pointed out the contradiction in the guideline:

Lorelei comes from Canada, where statistical outlier tests are recommended in the current drafted guideline – THX to Eric Ormsby!

If you want to follow EMA’s GL literally you have to act like a schizophrenic:

• no outlier test in the general case
  
• demonstrate that CV>30% of HVD(P)s is not caused by outlier(s) – but not by a statistical test

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Science Quotes

Complete thread:

• SAS Code for Outlier Detection in 2 way Crossover Study ashwinim13 2008-12-16 13:15 [Outliers] 
  • SAS Code for Outlier Detection in 2 way Crossover Study atish_azad 2008-12-17 06:22
    • SAS Code for Outlier Detection in 2 way Crossover Study ashwinim13 2008-12-17 09:31
  • Lund's test obsolete d_labes 2008-12-17 09:33
  • SAS Code for Outlier Detection in 2 way Crossover Study statistician 2010-05-25 11:07
    • Grubbs' test Helmut 2010-05-28 12:10
      • Grubbs' test KR 2010-05-31 15:18
        • Quoting and editing Helmut 2010-05-31 17:59
        • Outlier tests (EMA) Helmut 2010-06-08 15:15
          • EMA Outlier d_labes 2010-06-15 11:48
          • Outlier tests (EMA) Dr_Dan 2010-06-15 12:36
            • Outlier tests (EMA & Canada)Helmut 2010-06-15 12:56
              • EMA Outliers present d_labes 2010-06-15 15:40
                • EMA Outliers present Helmut 2010-06-15 15:59
                  • EMA Outliers present d_labes 2010-06-15 16:14
                    • EMA Outliers present Helmut 2010-06-15 16:29