Bioequivalence and Bioavailability Forum • Initial tube or duplicate ?

Initial tube or duplicate ? [Bioanalytics]

posted by Dr_Dan – Germany, 2010-06-08 14:08 (5846 d 11:59 ago) – Posting: # 5467
Views: 9,275

Dear Shuja
In some cases Ohlbe's suggestion to perform the incurred sample reanalyis from replicate samples could be right. I made the bad experience that the incurred sample reanalyis from the same samples failed but the incurred sample reanalyis from replicate samples passed. It was impossible to find out the reason for this observation but the difference was significant. We suspected additional metabolizing steps due to freeze and thaw. This was not observed during method validation.
Kind regards
Dan

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Kind regards and have a nice day
Dr_Dan

Complete thread:

Confirmatory reanalysis of Incurred Samples shujak1 2010-06-04 10:17 [Bioanalytics]
- Initial tube or duplicate ? Ohlbe 2010-06-05 00:23
  - Initial tube or duplicate ? shujak1 2010-06-08 06:05
    - Initial tube or duplicate ?Dr_Dan 2010-06-08 12:08
      - Initial tube or duplicate ? Ohlbe 2010-06-08 18:35
        
        Initial tube or duplicate ? shujak1 2010-06-09 06:06
        
        Initial tube or duplicate ? Dr_Dan 2010-06-09 11:30
        
        Initial tube or duplicate ? shujak1 2010-06-11 06:19
        
        Some desultory thoughts Helmut 2010-06-11 15:11
- Confirmatory reanalysis of Incurred Samples tusshar_adi 2010-06-24 18:55
- Confirmatory reanalysis of Incurred Samples Jagdish Bairagi 2010-07-27 16:02
  - Confirmatory reanalysis of Incurred Samples Helmut 2010-07-27 16:16