Bioequivalence and Bioavailability Forum • log to 3 decimals guess work

log to 3 decimals guess work [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2010-05-05 22:13 (5479 d 04:54 ago) – Posting: # 5302
Views: 24,958

Dear D, Labes,

Sorry to confuse you again. :-D

Actually it is not rounding, but directly transforming in bear.

❝ I guess that you compared the logs calculated to full precision

❝ TotalData$lnCmax <- log(TotalData$Cmax)

❝ lm(lnCmax ~ seq + subj:seq + prd + drug, data=TotalData)

❝ versus my suggestion

❝ lm(log(Cmax) ~ seq + subj:seq + prd + drug, data=TotalData).

Yes, this is exactly the way that we do in bear with the code as follow:


TotalData<-data.frame(subj = as.factor(Total$subj), drug = as.factor(Total$drug), Cmax = Total$Cmax, AUC0t = Total$AUC0t, AUC0INF = Total$AUC0INF,lnCmax = log(Total$Cmax),lnAUC0t = log(Total$AUC0t),lnAUC0INF = log(Total$AUC0INF))

❝ To get Helmut's concern change

❝ TotalData$lnCmax <- round(log(TotalData$Cmax),3)

❝ or even more drastically round to 2 decimals.

No! In bear, only "T/R ratio (%)" and "Power (%)" in "Sample size estimation" use round() function right now. Later (v2.5.0), in Welch t test, we will also use round() to present the point estimate and 90%CIs.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

F value for sequence effect Pakawadee 2010-05-03 11:48 [🇷 for BE/BA]
- F value for sequence effect AA 2010-05-03 13:38
- F value for sequence effect Ohlbe 2010-05-03 14:16
  - F value for sequence effect Pakawadee 2010-05-04 03:48
    - F value for sequence effect ElMaestro 2010-05-04 08:48
      - F value for sequence effect Pakawadee 2010-05-04 12:12
      - F value; rounding Helmut 2010-05-04 13:00
        
        log rounding machine d_labes 2010-05-04 13:35
        Rounding or not to rounding yjlee168 2010-05-04 21:27
        
        Rounding or not to rounding ElMaestro 2010-05-04 23:23
        
        Rounding or not to rounding yjlee168 2010-05-05 01:17
        
        Rounding or not to rounding ElMaestro 2010-05-05 12:15
        
        Rounding or not to rounding yjlee168 2010-05-05 12:59
        
        Rounding or not to rounding ElMaestro 2010-05-05 13:15
        
        Rounding or not to rounding yjlee168 2010-05-05 13:28
        Type III SS sequence effect -revised yjlee168 2010-05-05 23:58
        
        Type III SS sequence effect -revised ElMaestro 2010-05-06 07:27
        
        SAS-like Type III SS sequence with bear? yjlee168 2010-06-03 13:04
        
        New dataset? d_labes 2010-05-05 11:40
        
        New dataset? yjlee168 2010-05-05 12:31
        
        log to 3 decimals guess work d_labes 2010-05-05 16:00
        
        log to 3 decimals guess workyjlee168 2010-05-05 20:13
        
        rounding and presentation of data Helmut 2010-05-05 20:29
        
        rounding and presentation of data yjlee168 2010-05-05 21:05
        
        rounding and presentation of data in R martin 2010-05-06 07:53
        
        Canadian logs d_labes 2010-05-06 10:12
        
        Canadian logs ElMaestro 2010-05-06 10:21
        Canadian logs Helmut 2010-05-06 14:57
        
        Canadian lost d_labes 2010-05-06 15:38