Bioequivalence and Bioavailability Forum

New dataset? [🇷 for BE/BA]

posted by d_labes  – Berlin, Germany, 2010-05-05 13:40 (5479 d 13:31 ago) – Posting: # 5293
Views: 24,238

Dear Yung-jin,

if I look on your ANOVA results and the CIs I guess your single dose 2x2 cross-over dataset has changed?
Or is the difference solely due to rounding?

IMHO it would be a very good idea to have the same demo datasets across the various versions. With that given one can make a short test of the reliability of bear results and we are talking always about the same numbers regardless which bear version we have currently installed (sometimes called backward compatibility ).

It would also a very good idea to have the same datasets regardless if we start from NCA or later with statistical evaluation, i.e. the concentration-time values of a demo dataset should correspond to the PK metrics used later.

BTW: I question your results! Full match of the results with log to full precision or with log rounded to 3 digits (after dec. separator), respectively, in the ANOVA's and the CI's up to the last printed digits has a probability of very near to zero.

Complete thread:

• F value for sequence effect Pakawadee 2010-05-03 11:48 [🇷 for BE/BA] 
  • F value for sequence effect AA 2010-05-03 13:38
  • F value for sequence effect Ohlbe 2010-05-03 14:16
    • F value for sequence effect Pakawadee 2010-05-04 03:48
      • F value for sequence effect ElMaestro 2010-05-04 08:48
        • F value for sequence effect Pakawadee 2010-05-04 12:12
        • F value; rounding Helmut 2010-05-04 13:00
          • log rounding machine d_labes 2010-05-04 13:35
          • Rounding or not to rounding yjlee168 2010-05-04 21:27
            • Rounding or not to rounding ElMaestro 2010-05-04 23:23
              • Rounding or not to rounding yjlee168 2010-05-05 01:17
                • Rounding or not to rounding ElMaestro 2010-05-05 12:15
                  • Rounding or not to rounding yjlee168 2010-05-05 12:59
                    • Rounding or not to rounding ElMaestro 2010-05-05 13:15
                      • Rounding or not to rounding yjlee168 2010-05-05 13:28
                      • Type III SS sequence effect -revised yjlee168 2010-05-05 23:58
                        • Type III SS sequence effect -revised ElMaestro 2010-05-06 07:27
                          • SAS-like Type III SS sequence with bear? yjlee168 2010-06-03 13:04
            • New dataset?d_labes 2010-05-05 11:40
              • New dataset? yjlee168 2010-05-05 12:31
                • log to 3 decimals guess work d_labes 2010-05-05 16:00
                  • log to 3 decimals guess work yjlee168 2010-05-05 20:13
                    • rounding and presentation of data Helmut 2010-05-05 20:29
                      • rounding and presentation of data yjlee168 2010-05-05 21:05
                        • rounding and presentation of data in R martin 2010-05-06 07:53
                      • Canadian logs d_labes 2010-05-06 10:12
                        • Canadian logs ElMaestro 2010-05-06 10:21
                        • Canadian logs Helmut 2010-05-06 14:57
                          • Canadian lost d_labes 2010-05-06 15:38