Bioequivalence and Bioavailability Forum • F value; rounding

F value; rounding [🇷 for BE/BA]

posted by Helmut – Vienna, Austria, 2010-05-04 15:00 (5480 d 11:51 ago) – Posting: # 5282
Views: 24,423

Dear ElMaestro, Pakawadee and bears...

Hope to clarify the confusion. The example was calculated by bear v2.3.0 (not 'plain' R). I checked v2.4.1 on R2.9.0 and v2.4.2 on R2.10.1 - both use the correct error terms, i.e., MSE[(seq)] / MSE[subj(seq)].

Just discovered a little problem. bear log-transforms raw values and rounds them to three significant digits. That's nasty, because results will not agree with other software taking raw values as input and using logs in full precision.
From 2x2 example dataset, Cmax:


   subj drug seq prd Cmax lnCmax

1     1    1   2   2 1739 7.46

...

28   14    2   1   2 1718 7.45

bear (all versions?):
106.184 [97.550 - 115.582 ]
WinNonlin 5.3; 4-digit Cmax-values, logtransformation:
106.2319 [97.5839 - 115.6462]
WinNonlin 5.3; 3-digit lnCmax-values:
106.1837 [97.5479 - 115.5839]

IMHO it's pretty to have values in a nice formatted table, but log-transformed values should be treated internally in full precision.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

F value for sequence effect Pakawadee 2010-05-03 11:48 [🇷 for BE/BA]
- F value for sequence effect AA 2010-05-03 13:38
- F value for sequence effect Ohlbe 2010-05-03 14:16
  - F value for sequence effect Pakawadee 2010-05-04 03:48
    - F value for sequence effect ElMaestro 2010-05-04 08:48
      - F value for sequence effect Pakawadee 2010-05-04 12:12
      - F value; roundingHelmut 2010-05-04 13:00
        
        log rounding machine d_labes 2010-05-04 13:35
        Rounding or not to rounding yjlee168 2010-05-04 21:27
        
        Rounding or not to rounding ElMaestro 2010-05-04 23:23
        
        Rounding or not to rounding yjlee168 2010-05-05 01:17
        
        Rounding or not to rounding ElMaestro 2010-05-05 12:15
        
        Rounding or not to rounding yjlee168 2010-05-05 12:59
        
        Rounding or not to rounding ElMaestro 2010-05-05 13:15
        
        Rounding or not to rounding yjlee168 2010-05-05 13:28
        Type III SS sequence effect -revised yjlee168 2010-05-05 23:58
        
        Type III SS sequence effect -revised ElMaestro 2010-05-06 07:27
        
        SAS-like Type III SS sequence with bear? yjlee168 2010-06-03 13:04
        
        New dataset? d_labes 2010-05-05 11:40
        
        New dataset? yjlee168 2010-05-05 12:31
        
        log to 3 decimals guess work d_labes 2010-05-05 16:00
        
        log to 3 decimals guess work yjlee168 2010-05-05 20:13
        
        rounding and presentation of data Helmut 2010-05-05 20:29
        
        rounding and presentation of data yjlee168 2010-05-05 21:05
        
        rounding and presentation of data in R martin 2010-05-06 07:53
        
        Canadian logs d_labes 2010-05-06 10:12
        
        Canadian logs ElMaestro 2010-05-06 10:21
        Canadian logs Helmut 2010-05-06 14:57
        
        Canadian lost d_labes 2010-05-06 15:38