Parallel bears meeting at random in infinity [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2010-04-23 01:09 (5089 d 10:26 ago) – Posting: # 5189
Views: 55,742

Dear d_labes & ElMaestro,

❝ Call:

❝ lm(formula = lnAUC0t ~ drug + subj, data = TotalData)


Is this possible caused by unbalanced parallel data set? I changed the built-in dataset in the demo of parallel study as an unbalanced (subject in Test: 14's and 13's in Ref.) since bear v2.4.2 because it could cause error with previous version when the parallel was unbalanced when doing NCA. You can see the output file called Statistical_summaries.txt after running the demo dataset for more details. Therefore, I don't know if it is appropriate to use lm() to run unbalanced dataset as you did here. The reason to do that is only for my convenience when coding bear and testing it. The unbalanced dataset is quite special for an unbalanced, parallel BE study in bear. I got the bug information from a Greek user.

❝ Residuals:

❝ ALL 20 residuals are 0: no residual degrees of freedom!

(over-specified!)


❝ Coefficients: (1 not defined because of singularities)

❝ Estimate Std. Error t value Pr(>|t|)

❝ (Intercept) 7.3199 NA NA NA

❝ drug2 -0.0622 NA NA NA

❝ subj2 -0.5366 NA NA NA

❝ [...]


All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

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