IVIVC Studies [Dissolution / BCS / IVIVC]

posted by Helmut Homepage – Vienna, Austria, 2007-02-07 19:56 (5667 d 11:36 ago) – Posting: # 510
Views: 37,561

Dear Mamidi!

» Please tell me about how to proceed for IVIVC using the pilot data.

OK, you are going in the right direction, namely starting with in vivo data!

» Also can anybody tell me the important tests and procedure for IVIVC Studies using WinNonlin or any software (SAS, SPSS,.....).

Unless you want to start with parametric deconvolution, even M$-Excel will do the job (I would not trust the built-in Solver-routine)…
Kinetica offers templates for the ‘classical’ methods (Wagner-Nelson, Loo-Riegelman) and convolution/deconvolution.
If you have already a little experience with WinNonlin’s programming language, it should not be too difficult to implement any needed model manually.
An additional product (the IVIVC Tookit) is available for the latest release (5.2) of WinNonlin only.

» If there are any important sites regarding IVIVC kindly let me know.

Not directly IVIVC, but browse through the archive at Dissolution Technologies, and have a look at this nice review.

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