Bioequivalence and Bioavailability Forum

Already a PK-model? [Software]

posted by H_Rotter – Germany, 2010-04-08 22:07 (5494 d 07:20 ago) – Posting: # 5051
Views: 19,361

Dear Helmut!

❝ In my old studies...

How old?

❝ ...I fitted the last Ae-values vs. the end of the interval. Model: Ae=Ae_inf(1-e^-lambda_z·t)

As far as I know your model is correct for any renally cleared drug (regardless how many compartments are 'upstream' of the excretion process). But you can't linearize this function?! You do need some nonlinear fitting software. Comes close to 'compartmental models are not acceptable'.
Maybe that's the reason behind Far Side's method - ready to be checked by the assessor's pocket calculator.

❝ Pharsight's Extranet...

Not a very crowed place yet.

Regards,
Hermann

Complete thread:

• Pk parameter: Urine study (WinNonlin) AA 2010-04-07 07:01 [Software] 
  • Ae-inf based on rate Helmut 2010-04-07 18:26
    • Ae-inf based on rate AA 2010-04-08 14:08
      • Amount_ Recovered = Ae(0-t) Helmut 2010-04-08 14:27
    • Already a PK-model?H_Rotter 2010-04-08 20:07
      • Already a PK-model? Helmut 2010-04-08 20:47
        • Dinosaurs solution. d_labes 2010-04-09 09:31
          • Youngster's solution Helmut 2010-04-09 17:25
            • Some youngsters may be very old d_labes 2010-04-12 09:39
    • Ae-inf based on rate SDavis 2010-04-09 13:10
      • Replicate design studies in Phoenix/WinNonlin Helmut 2010-04-09 17:47