Orouboros mixed up [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2010-03-09 10:33 (5134 d 01:35 ago) – Posting: # 4882
Views: 23,592

Dear Helmut!

Oh, oh the orouboros has beaten again!

❝ ... But as a statistical amateur I don't get the point looking at the referred paper:

❝ Hsuan FC, Reeve R. Assessing individual bioequivalence with high-order cross-over designs: a unified procedure. Stat Med. 2003;22:2847–60.


I must confess that I had not understand this paper at all, thus being less than an amateur
("Blutiger Laie" = raw recruit :yes:).

❝ The method we proposed here has been implemented in a Pharsight™ product, WinNonlin® (version 3.2 or later).


Too bad I do not own WinNonlin.
Can you eventually show some output of this method?

What do you think about an adaption of

J.-P. Liu
Use of the repeated cross-over design in assessing bioequivalence
Statist. Med. 14, 1067-1078 (1995)

It has ANOVA tables but Liu term his model underlying the analysis "Mixed"!
Mixed effects for subject and subject*formulation interaction.
Without mixed effects the corresponding F-Tests would be others, I think.

Regards,

Detlew

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