Bioequivalence and Bioavailability Forum

bioanalytics (LLOQ) [General Sta­tis­tics]

posted by velupharm – 2007-01-24 06:36 (6743 d 15:23 ago) – Posting: # 486
Views: 14,465

❝ ❝ Also I would like to know with regard to AUC (0-last) that you have mentioned -Is this upto last quantifiable concentration or last concentration that you have measured.I have seen many people getting confused at this point.

❝

❝ Me too!

❝ What's the difference between a measured and a quantified concentration?

Dear HS
What actually I meant is the difference between measured and quantifiable concentration not quantified concentration.

Especially for longer halflife drugs, sometimes we may not capture adequately say 4-5 halflives (considering a non-truncated approach),despite a highly sensitive bio analytical method and in such cases whatever concentration we have captured with the last may not actually represent in AUC(0-last). In that case the last measured concentration shall not represent last quantifiable concentration
Also I would like to make it clear, whatever words I have used (Confused), shall not mean to criticise or comment particular person. If somebodies feelings have been hurted, kinly pardon me.

Complete thread:

• SR formulations hirenpharm 2007-01-20 10:05 
  • SR formulations - no MD study? Helmut 2007-01-22 19:09
    • SR formulations - no MD study? hirenpharm 2007-01-23 18:13
      • SR formulations - no MD study? Helmut 2007-01-23 18:32
  • SR formulations velupharm 2007-01-23 12:38
    • bioanalytics (LLOQ) Helmut 2007-01-23 19:59
      • bioanalytics (LLOQ)velupharm 2007-01-24 05:36
        • bioanalytics (LLOQ) Helmut 2007-01-24 12:40
          • bioanalytics (LLOQ) joyjac 2007-05-22 02:13
            • bioanalytics (LLOQ) Ohlbe 2007-05-24 23:02