bioanalytics (LLOQ) [General Sta­tis­tics]

posted by velupharm – 2007-01-24 06:36 (6496 d 18:01 ago) – Posting: # 486
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❝ ❝ Also I would like to know with regard to AUC (0-last) that you have mentioned -Is this upto last quantifiable concentration or last concentration that you have measured.I have seen many people getting confused at this point.


❝ Me too!

❝ What's the difference between a measured and a quantified concentration? :-D


Dear HS
What actually I meant is the difference between measured and quantifiable concentration not quantified concentration.

Especially for longer halflife drugs, sometimes we may not capture adequately say 4-5 halflives (considering a non-truncated approach),despite a highly sensitive bio analytical method and in such cases whatever concentration we have captured with the last may not actually represent in AUC(0-last). In that case the last measured concentration shall not represent last quantifiable concentration
Also I would like to make it clear, whatever words I have used (Confused), shall not mean to criticise or comment particular person. If somebodies feelings have been hurted, kinly pardon me. :-)

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