Bioequivalence and Bioavailability Forum • Bias?

Bias? [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2010-02-05 20:14 (5612 d 14:46 ago) – Posting: # 4719
Views: 24,318

Dear ElMaestro!

❝ ❝ Next I tortured the software and set R1 or R2 to ‘Missing’…

❝

❝ Something is wrong here, or I am not getting it right. If all R1's are missing then an R1 effect cannot be estimated (for example, a column with all zero's in the model matrix for that effect, or, a beta vector shortened by one because that effect is left out). Are you sure you deleted all objects prior to re-running the analysis?

OK, to be more precise: from the original dataset I generated two new ones: one with T and R1 and another one with T and R2, but the allocation to sequences and periods was kept 'as is'.

In WinNonlin-speak:

subject sequence period treatment response 1 response 2

  1        1       1       T        120.6      120.6

  1        1       2       R1        81.56      81.56

  1        1       3       R2      Missing    Missing

  …        …       …       …         …          …

and

subject sequence period treatment response 1 response 2

  1        1       1       T        120.6      120.6

  1        1       2       R1      Missing    Missing

  1        1       3       R2       136.7      146.7

  …        …       …       …         …         ...

I guess missing values in SAS-speak are denoted by a period ‘.’ instead.

❝ Since this goes off thread, I would be happy enough if this could be colported to its own thread.

Yes, maybe later on. There’s no way to do that directly by the forum’s software – manipulating the MySQL-backend calls for a fresher brain I’m having right now.

—
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Helmut Schütz

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Complete thread:

EMA BE guideline - final version Ohlbe 2010-01-28 18:31 [Regulatives / Guidelines]
- Final version published Helmut 2010-01-29 14:29
  - Final version published ElMaestro 2010-01-29 17:02
    - Statistix Helmut 2010-01-29 17:30
      - Statistix ElMaestro 2010-01-29 18:11
    - Calories ;-) Helmut 2010-01-29 19:22
      - Calories ;-) ElMaestro 2010-01-29 20:43
        
        Calories ;-) Helmut 2010-01-29 21:08
      - Variable calories d_labes 2010-02-01 12:05
    - ANOVA only - no doubts Helmut 2010-02-10 23:41
      - ANOVA only - no doubts ElMaestro 2010-02-12 21:09
  - Final EMA oracle d_labes 2010-02-01 11:53
    - Final EMA oracle Helmut 2010-02-01 12:28
    - Final EMA oracle ElMaestro 2010-02-01 12:50
      - More then two EMA oracles d_labes 2010-02-01 13:30
        
        Less of an issue ElMaestro 2010-02-01 15:29
        
        Less or More of an issue d_labes 2010-02-01 16:53
        
        Less or More of an issue ElMaestro 2010-02-01 17:22
        
        Effective with 1 Aug 2010 Helmut 2010-02-02 00:55
        Bias? ElMaestro 2010-02-04 11:27
        
        Bias? Helmut 2010-02-05 02:03
        
        Bias? ElMaestro 2010-02-05 09:33
        
        Bias? Helmut 2010-02-05 10:21
        
        Bias? d_labes 2010-02-05 13:59
        Bias? ElMaestro 2010-02-05 16:00
        
        Bias?Helmut 2010-02-05 19:14
      - Final EMA oracle Helmut 2010-02-01 13:43
        
        Final EMA oracle ElMaestro 2010-02-01 14:54
        
        Final EMA oracle d_labes 2010-02-01 15:20
        
        Teaching Helmut 2010-02-01 16:07
  - Cmin really gone? tmax reappeared? d_labes 2010-02-01 14:02
    - Cmin really gone. tmax reappeared - but how? Helmut 2010-02-01 23:30
  - Interpol or not d_labes 2010-02-01 14:52
    - Interpol! Helmut 2010-02-02 00:02
      - Interpol! ray_be 2010-02-03 18:31
        
        WinNonlin/Phoenix extrapolation to t=tau Helmut 2010-02-03 20:26
  - Meta-analysis Helmut 2010-02-07 17:41
  - Final version published Panks.79 2010-03-08 07:22
    - Cmin for MR-formulations? Helmut 2010-03-08 18:16
      - Cmin for MR-formulations? Marcel 2010-04-23 10:09
        
        MR-Guideline? Helmut 2010-04-23 12:34
- Overview of comments published Helmut 2010-02-10 18:33
  - Comments commented d_labes 2010-02-11 08:19
  - Definition of Cmin by EMEA Ravi 2010-03-13 12:05
    - The EMA’s Cmin & WinNonlin Helmut 2010-03-13 12:52