Bioequivalence and Bioavailability Forum • Too short tau?

Too short tau? [NCA / SHAM]

posted by Helmut – Vienna, Austria, 2010-01-13 20:14 (5594 d 20:08 ago) – Posting: # 4603
Views: 16,991

Dear Martin!

❝ Accumulation (e.g. higher AUC after repeated than after first administration) occurs when the dosing interval is "too short" with respect to the half-life of the compound investigated.

Veto!
If you get AUC_τ significantly (!) larger than AUC_∞ that’s not simply accumulation, but nonlinear PK (superposition principle does not hold). If your dosing interval is “too short”, you will get higher concentrations than you like (especially in toxicokinetics), but that's another story.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

extent of accumulation martin 2010-01-13 13:38 [NCA / SHAM]
- extent of accumulation ElMaestro 2010-01-13 16:15
  - extent of accumulation martin 2010-01-13 17:45
    - Too short tau?Helmut 2010-01-13 19:14
      - Too short tau? martin 2010-01-13 19:45
        
        Too short tau? Helmut 2010-01-13 20:02
    - extent of accumulation ElMaestro 2010-01-13 20:47
- extent of accumulation Helmut 2010-01-13 18:16
  - principle of superposition martin 2010-01-13 19:14
    - principle of superposition Helmut 2010-01-13 19:34