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RegisterA posteriori power [PK / PD]
posted by Helmut 
– Vienna, Austria, 2010-01-13 15:23 (5639 d 09:46 ago) – Posting: # 4596
Views: 8,322
Dear Ram!
Forget about 'power' (except in sample size planning, of course); see this post (and search for other posts). I know that this value is given in the output of Phoenix/WinNonlin – but please forget it. The outcome of a BE study is dichotomous – either you have demonstrated BE (confidence interval within the acceptance range), or not.
I agree with Ohlbe’s statement about following the protocol – but exclusion based on ‘lacking power’ would be a flawed concept anyway.
❝ and shall I exclude AUCinfinity from Bioequivalence if power is around 50 % … ?
Forget about 'power' (except in sample size planning, of course); see this post (and search for other posts). I know that this value is given in the output of Phoenix/WinNonlin – but please forget it. The outcome of a BE study is dichotomous – either you have demonstrated BE (confidence interval within the acceptance range), or not.
I agree with Ohlbe’s statement about following the protocol – but exclusion based on ‘lacking power’ would be a flawed concept anyway.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- AUC infinity kram 2010-01-13 11:06 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- AUC infinity Ohlbe 2010-01-13 11:35
- AUC infinity kram 2010-01-13 13:15
- EMA vs. FDA Ohlbe 2010-01-13 17:36
- AUC infinity kram 2010-01-13 13:15
- A posteriori powerHelmut 2010-01-13 14:23
- AUC infinity Ohlbe 2010-01-13 11:35
Ing. Helmut Schütz