Bioequivalence and Bioavailability Forum • Matrix Effect

Matrix Effect [Bioanalytics]

posted by Helmut – Vienna, Austria, 2009-12-28 15:18 (6025 d 16:42 ago) – Posting: # 4532
Views: 6,996

Dear Rajasekhar!

❝ What is the sufficient measure for matrix effect?

See one of my lectures (slides 9-10).

Concerning your other post I would proceed with the second method, because:

As Ohlbe stated previously you will be able to compensate for differences in ionisation (BTW, stable isotopes would do best), and
Protein precipitation is known to be the worst method if matrix effects are concerned (search the forum).

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Complete thread:

IS (polarity switching mode) drajasekhar 2009-12-27 10:43 [Bioanalytics]
- IS (polarity switching mode) Ohlbe 2009-12-28 01:00
  - LC-MS/MS method in the ionization Switching modes drajasekhar 2009-12-28 06:32
    - Recovery? Ohlbe 2009-12-30 13:51
      - Recovery? drajasekhar 2009-12-30 14:45
        
        Recovery vs. overall efficiency Ohlbe 2009-12-30 17:36
        
        Recovery vs. overall efficiency drajasekhar 2009-12-30 18:17
        
        Recovery vs. overall efficiency Ohlbe 2009-12-30 19:16
        Recovery vs. overall efficiency drajasekhar 2009-12-30 19:50
        Recovery vs. overall efficiency Helmut 2009-12-30 19:58
        
        Recovery vs. overall efficiency drajasekhar 2009-12-30 20:35
        
        Recovery vs. overall efficiency Helmut 2009-12-30 20:38
        Recovery vs. overall efficiency Ohlbe 2009-12-30 20:43
        
        Recovery vs. overall efficiency drajasekhar 2009-12-30 20:54
  - Matrix Effect drajasekhar 2009-12-28 07:00
    - Matrix EffectHelmut 2009-12-28 14:18
    - Matrix Effect Ohlbe 2009-12-30 13:53

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