Bioequivalence and Bioavailability Forum

Dear HS,

Thank for this and for the reference. I can learn a lot, and there is a loooooong way to go for me.

I wonder about a issue that is on the border between philosophy and statistics... Analysis of Log C_max is generally based on the assumption that the residuals are normal. If we subsequently also want to qualify Log C_min with some kind of statistic can we then conduct such an analysis with parametric statistics? Once we identify Log C_max we know that the rest will be smaller than that value. Hence, there are constraints on the magnitudes of the residuals in the analysis of Log C_min and therefore I would be inclined to think we violate an important assumption in parametric statistics?

(I shall abstain from proposing parametric statistics as a potential alternative, notch notch wink wink!)

Best regards,
EM.