Cmin (EU) [Surveys]

posted by ElMaestro  – Denmark, 2009-12-22 15:17 (5210 d 17:18 ago) – Posting: # 4518
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Hi HS,

I am not the one to answer this interesting question, and I hope there will be some input from more qualified people.

Clearly I would use option 1b; if pre-dose is not the lowest in practice then we are looking at data that do not reflect reality but random fluctuations or mixups (unless, of course, the body is capable of synthesizing the drug or metabolite under investigation which is generally not the case for the majority of substances). And in fact Cmin,ss is to some people like me a misnomer; should be called Ctrough, with trough being defined as predose.

My 0.02 euros.
EM.

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