Bioequivalence and Bioavailability Forum • Statistics in multiple dose study

Statistics in multiple dose study [NCA / SHAM]

posted by ratnakar1811 – India, 2009-12-04 09:21 (5616 d 19:47 ago) – Posting: # 4429
Views: 11,553

Dear HS,

Thanks for your guidance, now I have a last question relating to taking of minimum three pre-dose sample prior to dosing of day4 as per your advice and suggested in guidline.

Now should we take pre-dose samples prior to dosing of day-3 (1600 of day2, 0800, 1600 of day3 and 2400 of day3 which is same as that of pre-dose of day-4)?

OR

Pre-dose of all 0800hr dosing from day 1-4?

Thanks

Ratnakar

Complete thread:

Statistics in multiple dose study ratnakar1811 2009-12-01 11:09 [NCA / SHAM]
- Statistics in multiple dose study Helmut 2009-12-02 00:20
  - Statistics in multiple dose study ratnakar1811 2009-12-03 07:36
    - Statistics in multiple dose study Helmut 2009-12-03 14:53
      - Statistics in multiple dose studyratnakar1811 2009-12-04 08:21
  - Metrics for multiple profiles d_labes 2009-12-03 08:58
    - Metrics for multiple profiles Helmut 2009-12-03 15:50
      - Metrics for multiple profiles d_labes 2009-12-03 16:02
        
        Metrics for multiple profiles Helmut 2009-12-03 16:11
      - PTF is another story d_labes 2009-12-03 16:17
        
        PTF is another story Helmut 2009-12-03 16:42
        
        the flatter is better? d_labes 2009-12-04 08:46
        
        Biopharmaceutical history Helmut 2009-12-04 12:35