Missing samples in terminal elimination phase [Study As­sess­ment]

posted by Bhupesh  – India, 2009-10-12 16:14 (5308 d 10:14 ago) – Posting: # 4339
Views: 7,261

Dear All
Regards :-)

Few days back, we did a parallel bioequivalance study for a molecule with long half life (terminal elimination half life between 120 hr - 156 hr) and have sampling points up to 720 hrs post dose.

Due to longer study period, there were some missing ambulatory samples (In one volunteer missed 3 samples between 72 - 144 hr) and in others missing some samples after 144 hr.

Tmax of the molecule was said to be in between 6 - 24 hr.

Can anyone please suggest a reliable estimation of AUC0-t considering the missing samples.

Thanks and Regards

Bhupesh

Edit: Category changed. [Helmut]

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