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RegisterBalaam's design, sample size [General Statistics]
Dear Helmut,
For the sample size calculation have a look into
It comes out that the sample size needed for the Balaam's design is approx. twice that of a common classical 2x2 cross-over.
❝ [...] On the other hand ANVISA states Balaam's design in their guideline. Don't ask me about sample size calculations - no idea…
For the sample size calculation have a look into
K.-W. Chen, S.-C. Chow and G. Li
A Note on Sample Size Determination for Bioequivalence Studies with Higher-order Crossover Designs
J. Pharmacokinetics and Biopharmaceutics, Vol. 25, No. 6, p753-765 (1997)
It comes out that the sample size needed for the Balaam's design is approx. twice that of a common classical 2x2 cross-over.
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Regards,
Detlew
Regards,
Detlew
Complete thread:
- Balaam's design graveendranath 2009-09-23 09:13 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Balaam's design Helmut 2009-09-23 12:47
- Balaam's design, sample sized_labes 2009-09-24 16:13
- Balaam's design graveendranath 2009-09-25 12:23
- Balaam's design, intra-subject variances d_labes 2009-09-29 14:44
- Balaam's design, intra-subject variances graveendranath 2009-09-30 13:59
- Balaam's design, intra-subject variances d_labes 2009-09-29 14:44
- Balaam's design, sample size Helmut 2009-09-25 15:44
- Balaam's design, sample size doubled one more time d_labes 2009-09-28 11:58
- Balaam's design graveendranath 2009-09-25 12:23
- Balaam's design, sample sized_labes 2009-09-24 16:13
- Balaam's design Helmut 2009-09-23 12:47
Ing. Helmut Schütz