Bioequivalence and Bioavailability Forum • Paper, pencil, brain ;-)

Paper, pencil, brain ;-) [Software]

posted by yuvrajkatkar – Pune, Maharashtra (India), 2009-09-22 18:09 (6103 d 22:28 ago) – Posting: # 4229
Views: 32,291

Dear Sir,

As per your lecture "Statistical design and analysis II"
n1=21,n2=21
PE=sqrt(1.08*1.33)=1.20
delta CL=lnCLhi-lnPE=ln(1.33)-ln(1.20)=0.10408911
alpha=0.05
t1-2*alpha,n1+n2-2=1.68385101

MSE=2*[deltaCL/(sqrt((1/n1)+(1/n2))*t1-2*alpha,n1+n2-2)]^2

   =0.080245847

SEdifference=sqrt(2*MSE/42)=0.061816105

CVintra=100*sqrt(exp(MSE)-1)

       =100*sqrt(exp(0.080245847)-1)

       =28.9%

which is nearly equal to 29%

90% CI for Upper limit

=EXP(ln(T/R)+1.68385101*SEdifference)

                       =EXP(0.181035485+1.68385101*0.061816105)

                       =1.329927721

which is nearly equal to 1.33

90% CI for Lower limit

=EXP(ln(T/R)-1.68385101*SEdifference)

                       =EXP(0.181035485-1.68385101*0.061816105)

                       =1.07998416

which is nearly equal to 1.08

Is it right, Sir?

Edit: Reformatted using BBCodes. [Helmut]

—
Best Regards,
Yuvraj

Complete thread:

Sample Size Calculation sasikumar 2008-04-03 09:19 [Software]
- Sample Size Calculation (SAS) Jaime_R 2008-04-03 13:13
- Sample Size Calculation d_labes 2008-04-23 11:54
  - Sample Size Calculation balakotu 2009-09-07 07:51
  - Sample Size Calculation yuvrajkatkar 2009-09-19 09:24
    - Paper, pencil, brain ;-) Helmut 2009-09-19 11:48
      - Paper, pencil, brain ;-) yuvrajkatkar 2009-09-21 15:10
        
        Paper, pencil, brain ;-) Helmut 2009-09-21 15:23
        Paper, pencil, brain ;-) Helmut 2009-09-21 18:33
        
        Paper, pencil, brain ;-)yuvrajkatkar 2009-09-22 16:09
        
        No paper, pencil, brain :-( Helmut 2009-09-22 18:22
        
        about your lectures yuvrajkatkar 2009-09-23 07:27
        
        About Trust Helmut 2009-09-23 13:50
        
        sample size calculation yuvrajkatkar 2009-10-01 13:33
        
        inter- / intra- / total variance Helmut 2009-10-01 13:52
        
        inter- / intra- / total variance yuvrajkatkar 2009-10-01 17:13
        
        Theta?! Helmut 2009-10-01 17:30
        
        sample size for parallel design yuvrajkatkar 2009-10-03 07:44
        
        Reference? Helmut 2009-10-03 13:46
        
        MSE obtain from Parallel study in WinNonlin yuvrajkatkar 2009-10-09 16:46
        
        Parallel study in WinNonlin Helmut 2009-10-10 10:51