Bioequivalence and Bioavailability Forum • 2-sequence, 2-period, 2-trt crossover design (R, SAS)

2-sequence, 2-period, 2-trt crossover design (R, SAS) [Software]

posted by Pingouinche – France, 2009-08-19 13:39 (5725 d 16:05 ago) – Posting: # 4061
Views: 10,680
(edited on 2009-08-19 16:21)

Hello,

I'm new at BA/BE studies and I don't understand very well how to analyze a crossover experiment with R or SAS.

I'm trying to replicate the results I've read in a book (Design and analysis of bioavailability and bioequivalence studies): a complete example is proposed in section 3.6, data is p.73 and the classic ANOVA table I want to obtain is p.78.

I would like to know how I can obtain such an ANOVA table with R or SAS, with inter- and intra- source of variations separated.

I don't manage to write properly the model, in order to make SAS or R understand that each subject has two measures, and that some factors have to be tested between subject, and others within subjects.

Do you a have a document, or a code "ready to use" which could help me to replicate the results of the book ?

Thanks !

Edit: Subject line changed. [Helmut]

Complete thread:

2-sequence, 2-period, 2-trt crossover design (R, SAS)Pingouinche 2009-08-19 11:39 [Software]
- 2-sequence, 2-period, 2-trt crossover design (R, SAS) Pingouinche 2009-08-19 16:21
  - R, SAS- codes Helmut 2009-08-19 17:05
    - R, SAS- codes Pingouinche 2009-08-19 22:20
      - R, SAS- codes Helmut 2009-08-20 01:12
        
        R, SAS- codes Pingouinche 2009-08-20 09:19
  - 2-sequence, 2-period, 2-trt crossover design (R, SAS) yjlee168 2009-08-19 18:42
    - 2-sequence, 2-period, 2-trt crossover design (R, SAS) Helmut 2009-08-20 01:19
      - 2-sequence, 2-period, 2-trt crossover design (R, SAS) yjlee168 2009-08-20 12:02
  - 2-sequence, 2-period, 2-trt crossover design (R, SAS) yjlee168 2009-08-20 12:17