Bioequivalence and Bioavailability Forum

Dear all colleagues,

We have uploaded bear v2.4.0 to CRAN ftp servers. Please use "update package" to upgrade from previous version from R console. Do NOT download the .zip file from CRAN ftp mirror directly and install this version as the "local zip file", since we have added some new features from some new R packages. The procedure of local zip file installation only installs bear without updating its R packages used. That may cause errors when you do "library(bear)" at R console. If you have done that way, you have to install these packages manually in this situation. Also, please try to upgrade your R to the current (v2.9.1) when running bear.

In this release, we add following new features:

1. BE/BA data analysis with multiple-dose design, either crossover or parallel;
   
2. Cook's distance for outlier detection in crossover study (including multiple dose and single dose) and the output file, ANOVA_stat.txt. This function has been validated using SAS; and
   
3. y-axis scaling problems fixed.

bear: Average bioequivalence and bioavailability data analysis tool

An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental analysis (NCA), ANOVA (lm) for a standard RT/TR 2x2x2 crossover design and linear mixed effect model (lme of nlme) for a 2-treatment, 2-sequence, with 2 periods or more (i.e. 2x2x3/2x2x4) replicate design or a 2-treatment, 2-sequence, and 1-period parallel ABE study (2x2x1).
Version:    2.4.0
Depends:    R (>= 2.8.0), reshape, nlme, sciplot, plotrix, ICSNP, gdata <-- all packages used in bear
Published:  2009-07-21
Author:     Hsin-ya Lee, Yung-jin Lee
Maintainer: Hsin-ya Lee <hsinyalee at gmail.com>
License:    GPL (>= 2)
URL:        http://pkpd.kmu.edu.tw/bear

Thank you all.