half-life in multiple-dosed steady-state BE/BA study? [NCA / SHAM]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2009-07-14 14:16 (4575 d 07:43 ago) – Posting: # 3954
Views: 14,692

Dear All,

I just like to know if it is reasonable to estimate lambdaz when doing data analysis of a multiple-dosed steady-state (SS) BE/BA study. It is because we just collect the plasma/blood sample within one dosing interval (Tau) at steady-state in a multiple-dosed BE/BA study. It looks like there is no such terminal phase at all in multiple-dosed BE/BA study. If it is not reasonable, is there any way to estimate the elimination rate constant (kel), half-life, Vss or the accumulation index? In WinNonlin v5.x, lambdaz still needs to be estimated first for further calculations of other NCA parameters. Thanks in advanced.

All the best,
-- Yung-jin Lee
bear v2.9.0:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Activity
 Admin contact
21,835 posts in 4,569 threads, 1,554 registered users;
online 3 (0 registered, 3 guests [including 2 identified bots]).
Forum time: Saturday 20:59 CET (Europe/Vienna)

Science may set limits to knowledge,
but should not set limits to imagination.    Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5