Bioequivalence and Bioavailability Forum

Dear HS,

thanks, but I think I formulated myself wrongly; I agree with almost everything you say but what I meant was something else. I will try to "reformulate" (that's a forbidden word otherwise!):

The weighting scheme I encounter now and then is the 1/x or 1/x². Lets for the time being forget the 1/y or 1/y² (which deserves discussion in another thread).
As you point out the choice of weights has to do with variabilities, if the variability goes up as x increases then we weight accordingly in order to make sure that the points corresponding to high x values are not given the same priority as the numbers corresponding to low x values. But we could in theory achieve the same by having "less points at high x-values and more points at low x-values" and then use no weights. Implementing the equation you have given above would correspond pretty well to that concept. Therefore, my intuition tells me that your equation is intended for a situation with no weights and where the variability is not constant.


Best regards
EM.