Log in
Registerratio of dose-adjusted AUCs [Regulatives / Guidelines]
dear hs!
what do you think about comparing dose-adjusted AUCs? on assumption of dose-proportionality the ratio of dose-adjusted AUCs should be one.
in case of more than two dose-levels, application of an adequate stepwise testing procedure (based on the closed testing approach) on dose-adjusted AUCs can help to identify the dose-range where dose-proportionality holds. this approach keeps the familywise error rate at the pre-specified alpha-level which should be more powerful than the application of the bonferroni correction.
I am looking forward to your opinion on this topic
best regards
Martin
what do you think about comparing dose-adjusted AUCs? on assumption of dose-proportionality the ratio of dose-adjusted AUCs should be one.
in case of more than two dose-levels, application of an adequate stepwise testing procedure (based on the closed testing approach) on dose-adjusted AUCs can help to identify the dose-range where dose-proportionality holds. this approach keeps the familywise error rate at the pre-specified alpha-level which should be more powerful than the application of the bonferroni correction.
I am looking forward to your opinion on this topic
best regards
Martin
Complete thread:
- Dose proportionality Ravi 2009-05-15 07:43 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Dose proportionality Helmut 2009-05-16 00:44
- ratio of dose-adjusted AUCsmartin 2009-05-16 11:33
- ratio of dose-adjusted AUCs Helmut 2009-05-16 16:24
- ratio of dose-adjusted AUCsmartin 2009-05-16 11:33
- Dose proportionality Helmut 2009-05-16 00:44
Ing. Helmut Schütz