Bioequivalence and Bioavailability Forum • FDA loves SAS code? definitely.

FDA loves SAS code? definitely. [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2009-04-23 12:46 (5862 d 11:59 ago) – Posting: # 3590
Views: 68,283

Dear D. Labes,

Sorry about the code. :-D

Here is the correct one.

proc mixed data=blabla;

class seq subj prd tmt;

model lnAUC=seq prd tmt/ ddfm=kenwardroger;

random subj(seq);

lsmeans tmt/pdiff cl alpha=0.1;

estimate ’ABE for lnAUC’ tmt -1 1; run;

I've changed the parameter names to fit our discussion.

❝ where does the code come from?

❝ I cannot find it in Jones / Kenward.

Ch. 7.

❝ And what about the DDFM=blabla? I have learned so far (in reading tons of Web sites) that there is no such thing as different denominator degrees of freedom methods in lme()?

Nope, we cannot find equivalent one, either.

❝ BTW: Kenward/Jones in their Proc MIXED code always use DDFM=KR, i.e. the Kenward/Roger method. Not so astonishing I think :-D .

Yes, you're right.

❝ BTW2: Let me state explicitly that these discussions are not for proving you / bear wrong. I am seriously on the way to change "The power to know" to R, but only if I can fulfill the needs in statistics for bioequivalence studies (regulators bullet proof), my everyday bread and butter work.

Wow. You can choose both, can't you? If you can't, better stay with Power to know for now.

❝ And currently I suspect that this is not feasible for replicate studies. Or is anybody out there to prove me that black is white?

no luck so far.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Freedom for replicate bears d_labes 2009-04-17 12:06 [🇷 for BE/BA]
- Freedom for replicate bears ElMaestro 2009-04-17 14:50
  - Contain does not contain d_labes 2009-04-17 15:07
- Freedom for replicate bears ElMaestro 2009-04-18 03:45
  - Freedom incompatible with baseball bats d_labes 2009-04-20 08:42
- Freedom for replicate bears yjlee168 2009-04-19 21:38
  - Freedom to some degree d_labes 2009-04-20 08:30
    - Freedom to some degree yjlee168 2009-04-21 14:03
      - FDA loves replicate bears? d_labes 2009-04-21 16:11
        
        Cholesky factor ?! Helmut 2009-04-22 00:46
        
        Cholesky factor ?! d_labes 2009-04-22 11:20
        
        FDA loves replicate bears? yjlee168 2009-04-23 08:08
        
        FDA loves SAS code? d_labes 2009-04-23 09:48
        
        FDA loves SAS code? definitely.yjlee168 2009-04-23 10:46
        
        SAS? or R? or what? d_labes 2009-04-23 15:07
        
        SAS? or R? or what? Helmut 2009-04-23 15:25
        
        SAS? or R? or what? d_labes 2009-04-23 16:06
        
        SAS? or R? or what? Helmut 2009-04-23 16:30
        
        SAS? YES; R? why not? as long as they are useful... yjlee168 2009-04-23 19:56
        
        New Forum-Category 'bear'? Helmut 2009-04-23 20:03
        
        New Forum-Category 'bear'? yjlee168 2009-04-23 20:19
        
        New Forum-Category 'R for BE/BA' Helmut 2009-04-23 20:37
        
        New Forum-Category 'R for BE/BA' yjlee168 2009-04-24 09:19
        
        Replicated again d_labes 2009-04-24 08:27
        
        Replicated again yjlee168 2009-04-24 09:26
- getting decimals ElMaestro 2010-06-03 05:21
  - getting decimals yjlee168 2010-06-03 08:37
    - getting decimals ElMaestro 2010-06-04 01:59
- Freedom for replicate bears ElMaestro 2011-01-27 21:50
  - lmer vs. lme d_labes 2011-01-28 09:02
    - lmer vs. lme ElMaestro 2011-01-28 09:42
      - lmer vs. lme d_labes 2011-01-28 11:37
        
        V ElMaestro 2011-01-28 12:14
        
        V corrected d_labes 2011-01-28 14:12
        
        V corrected ElMaestro 2011-01-28 15:20
        
        Peculiar partial replicate d_labes 2011-01-28 16:10