Freedom to some degree [R for BE/BA]

posted by d_labes  – Berlin, Germany, 2009-04-20 08:30 (4612 d 17:01 ago) – Posting: # 3568
Views: 64,429

Dear bears, dear all

» You can try "options (digits=n)" in R console to increase decimals, where n the number decimal you like to splay. If not work, it can be the built-in option in the package.

Of course I had tried this.
Unfortunately all this doesn't help here.

» But as I can remember, we had validated 90%CI obtained from bears with those from SAS with replicate study using lme(). I will post the results here later. Basically we got the equivalent 90%CIs with SAS. Indeed, we know DenDFs obtained from bears are different from those using SAS. However, 90% CIs are the same.

Don't worry about this, because SAS and bear gave the same result (also with DDFM=SATTERTHWAITE or KR) as long as
  lme(y~tmt+period+sequence, random=1|subject, data=blabla)
and the Proc MIXED equivalent of that is used. The difference comes only into effect if one tries to implement the FDA model (which is mandatory I think, at least for studies aimed to the FDA regulated market).

My questions remains:
Do I do something wrong here? If yes, what?
If not, what are the chances that regulators accept the bear / R handling of replicate studies?

Regards,

Detlew

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