Freedom to some degree [🇷 for BE/BA]
Dear bears, dear all
Of course I had tried this.
Unfortunately all this doesn't help here.
Don't worry about this, because SAS and bear gave the same result (also with DDFM=SATTERTHWAITE or KR) as long as
and the Proc MIXED equivalent of that is used. The difference comes only into effect if one tries to implement the FDA model (which is mandatory I think, at least for studies aimed to the FDA regulated market).
My questions remains:
Do I do something wrong here? If yes, what?
If not, what are the chances that regulators accept the bear / R handling of replicate studies?
❝ You can try "options (digits=n)" in R console to increase decimals, where n the number decimal you like to splay. If not work, it can be the built-in option in the package.
Of course I had tried this.
Unfortunately all this doesn't help here.
❝ But as I can remember, we had validated 90%CI obtained from bears with those from SAS with replicate study using lme(). I will post the results here later. Basically we got the equivalent 90%CIs with SAS. Indeed, we know DenDFs obtained from bears are different from those using SAS. However, 90% CIs are the same.
Don't worry about this, because SAS and bear gave the same result (also with DDFM=SATTERTHWAITE or KR) as long as
lme(y~tmt+period+sequence, random=1|subject, data=blabla)
and the Proc MIXED equivalent of that is used. The difference comes only into effect if one tries to implement the FDA model (which is mandatory I think, at least for studies aimed to the FDA regulated market).
My questions remains:
Do I do something wrong here? If yes, what?
If not, what are the chances that regulators accept the bear / R handling of replicate studies?
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Freedom for replicate bears d_labes 2009-04-17 12:06 [🇷 for BE/BA]
- Freedom for replicate bears ElMaestro 2009-04-17 14:50
- Contain does not contain d_labes 2009-04-17 15:07
- Freedom for replicate bears ElMaestro 2009-04-18 03:45
- Freedom incompatible with baseball bats d_labes 2009-04-20 08:42
- Freedom for replicate bears yjlee168 2009-04-19 21:38
- Freedom to some degreed_labes 2009-04-20 08:30
- Freedom to some degree yjlee168 2009-04-21 14:03
- FDA loves replicate bears? d_labes 2009-04-21 16:11
- Cholesky factor ?! Helmut 2009-04-22 00:46
- Cholesky factor ?! d_labes 2009-04-22 11:20
- FDA loves replicate bears? yjlee168 2009-04-23 08:08
- FDA loves SAS code? d_labes 2009-04-23 09:48
- FDA loves SAS code? definitely. yjlee168 2009-04-23 10:46
- SAS? or R? or what? d_labes 2009-04-23 15:07
- SAS? or R? or what? Helmut 2009-04-23 15:25
- SAS? or R? or what? d_labes 2009-04-23 16:06
- SAS? or R? or what? Helmut 2009-04-23 16:30
- SAS? or R? or what? d_labes 2009-04-23 16:06
- SAS? YES; R? why not? as long as they are useful... yjlee168 2009-04-23 19:56
- New Forum-Category 'bear'? Helmut 2009-04-23 20:03
- New Forum-Category 'bear'? yjlee168 2009-04-23 20:19
- New Forum-Category 'R for BE/BA' Helmut 2009-04-23 20:37
- New Forum-Category 'R for BE/BA' yjlee168 2009-04-24 09:19
- New Forum-Category 'R for BE/BA' Helmut 2009-04-23 20:37
- New Forum-Category 'bear'? yjlee168 2009-04-23 20:19
- Replicated again d_labes 2009-04-24 08:27
- Replicated again yjlee168 2009-04-24 09:26
- New Forum-Category 'bear'? Helmut 2009-04-23 20:03
- SAS? or R? or what? Helmut 2009-04-23 15:25
- SAS? or R? or what? d_labes 2009-04-23 15:07
- FDA loves SAS code? definitely. yjlee168 2009-04-23 10:46
- FDA loves SAS code? d_labes 2009-04-23 09:48
- Cholesky factor ?! Helmut 2009-04-22 00:46
- FDA loves replicate bears? d_labes 2009-04-21 16:11
- Freedom to some degree yjlee168 2009-04-21 14:03
- Freedom to some degreed_labes 2009-04-20 08:30
- getting decimals ElMaestro 2010-06-03 05:21
- getting decimals yjlee168 2010-06-03 08:37
- getting decimals ElMaestro 2010-06-04 01:59
- getting decimals yjlee168 2010-06-03 08:37
- Freedom for replicate bears ElMaestro 2011-01-27 21:50
- lmer vs. lme d_labes 2011-01-28 09:02
- lmer vs. lme ElMaestro 2011-01-28 09:42
- lmer vs. lme d_labes 2011-01-28 11:37
- V ElMaestro 2011-01-28 12:14
- V corrected d_labes 2011-01-28 14:12
- V corrected ElMaestro 2011-01-28 15:20
- Peculiar partial replicate d_labes 2011-01-28 16:10
- V corrected ElMaestro 2011-01-28 15:20
- V corrected d_labes 2011-01-28 14:12
- V ElMaestro 2011-01-28 12:14
- lmer vs. lme d_labes 2011-01-28 11:37
- lmer vs. lme ElMaestro 2011-01-28 09:42
- lmer vs. lme d_labes 2011-01-28 09:02
- Freedom for replicate bears ElMaestro 2009-04-17 14:50