## Freedom for replicate bears [R for BE/BA]

Dear D. Labes,

»
» Replicate berlin buddy bears

very cute. I like that!

» The key statement in bear for evaluating replicate BE studies (astonishing enough claimed as only 2-sequence designs allowed?) is

I think we can easily program bears to handle ABE data from more than 2 seq and/or more than 2 tmt in the future.

» [...]
» tmtR     0.14901302 tmtR
» tmtT     0.12216340 0.15 any body out there who knows how to get more decimals here?

You can try "options (digits=n)" in R console to increase decimals, where n the number decimal you like to display. If not work, it can be the built-in option in the package.

» [...] But all other available DDFM in Proc MIXED gave not a denDF=38 for the treatment effect. One gets always lower denDF in SAS and as a consequence of that wider 90% confidence intervals!

But as I can remember, we had validated 90%CI obtained from bears with those from SAS with replicate study using lme(). I will post the results here later. Basically we got the equivalent 90%CIs with SAS. Indeed, we know DenDFs obtained from bears are different from those using SAS. However, 90% CIs are the same.

All the best,
-- Yung-jin Lee
bear v2.9.0:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear