Bioequivalence and Bioavailability Forum • Freedom for replicate bears

Freedom for replicate bears [🇷 for BE/BA]

posted by ElMaestro – Denmark, 2009-04-17 16:50 (5486 d 10:32 ago) – Posting: # 3556
Views: 66,181

Hi dlabes,

❝ Or is the denominator DF question also like type III SumOfSquares? (I have read some Websites indicating that).

As far as I recall, the R default -with no option to change it- is to use a denDF which is similar to SAS' "containment" meffud. I you insist on having Satterthwaite's denDF or whatever, then R will not be your package of choice. One little problem is that FDA indirectly endorsed SAS some time ago, so many regulators (incl. EU) expect an output which can be replicated with SAS using FDA scripts. Then clearly R will fall short of the goal. I guess you can safely conclude this is another "type III SS" or LSMean phenomenon. Big bro dictates the standard and regulators have no clue. Do it the SAS way or do it wrong. OK, that was a provocation, sorry.

One can go on and on; discussion of the proof that REML gives unbiased
coefficients in unbalanced datasets comes next, I guess?

Best regards
EM.

Complete thread:

Freedom for replicate bears d_labes 2009-04-17 12:06 [🇷 for BE/BA]
- Freedom for replicate bearsElMaestro 2009-04-17 14:50
  - Contain does not contain d_labes 2009-04-17 15:07
- Freedom for replicate bears ElMaestro 2009-04-18 03:45
  - Freedom incompatible with baseball bats d_labes 2009-04-20 08:42
- Freedom for replicate bears yjlee168 2009-04-19 21:38
  - Freedom to some degree d_labes 2009-04-20 08:30
    - Freedom to some degree yjlee168 2009-04-21 14:03
      - FDA loves replicate bears? d_labes 2009-04-21 16:11
        
        Cholesky factor ?! Helmut 2009-04-22 00:46
        
        Cholesky factor ?! d_labes 2009-04-22 11:20
        
        FDA loves replicate bears? yjlee168 2009-04-23 08:08
        
        FDA loves SAS code? d_labes 2009-04-23 09:48
        
        FDA loves SAS code? definitely. yjlee168 2009-04-23 10:46
        
        SAS? or R? or what? d_labes 2009-04-23 15:07
        
        SAS? or R? or what? Helmut 2009-04-23 15:25
        
        SAS? or R? or what? d_labes 2009-04-23 16:06
        
        SAS? or R? or what? Helmut 2009-04-23 16:30
        
        SAS? YES; R? why not? as long as they are useful... yjlee168 2009-04-23 19:56
        
        New Forum-Category 'bear'? Helmut 2009-04-23 20:03
        
        New Forum-Category 'bear'? yjlee168 2009-04-23 20:19
        
        New Forum-Category 'R for BE/BA' Helmut 2009-04-23 20:37
        
        New Forum-Category 'R for BE/BA' yjlee168 2009-04-24 09:19
        
        Replicated again d_labes 2009-04-24 08:27
        
        Replicated again yjlee168 2009-04-24 09:26
- getting decimals ElMaestro 2010-06-03 05:21
  - getting decimals yjlee168 2010-06-03 08:37
    - getting decimals ElMaestro 2010-06-04 01:59
- Freedom for replicate bears ElMaestro 2011-01-27 21:50
  - lmer vs. lme d_labes 2011-01-28 09:02
    - lmer vs. lme ElMaestro 2011-01-28 09:42
      - lmer vs. lme d_labes 2011-01-28 11:37
        
        V ElMaestro 2011-01-28 12:14
        
        V corrected d_labes 2011-01-28 14:12
        
        V corrected ElMaestro 2011-01-28 15:20
        
        Peculiar partial replicate d_labes 2011-01-28 16:10