Evaluation of Reference variability [Design Issues]

posted by Ravi  – India, 2009-04-14 06:25  – Posting: # 3519
Views: 2,426

Dear Nirali,

To check for reference variablity you can use modified replicate design i.e. 3 period, 3 sequence and 2 treatment crossover design with sequences as RTR, RRT, TRR. But this design will provide you with intra CV for reference only. For more details please have alook at
Bioequivalence Approaches for Highly Variable Drugs and Drug Products by Sam H. Haidar.

I hope this helps.

Thanks & Regards
Ravi Pandey

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