Exclusion of subjects who are not in SS [Software]

posted by KR – India, 2009-04-13 14:34 (4870 d 11:02 ago) – Posting: # 3516
Views: 16,000

(edited by Ohlbe on 2009-04-13 22:30)

Dear Helmut,

Adding to that, if dosing interval for reference product is 24 hours and that of test product is 12 hours i.e. tau=24 hrs. for reference and tau=12 hrs. for test product then how can we calculate AUCtau ? means if we put tau=12 hrs. for test product in the model then which AUC area will be estimated by WinNonlin i.e first 0-12 hrs or last 0-12 hrs ?

Moreover, if we calculate AUC0-24 for both test and reference in above case then how WinNonlin calculates ? Should i give common dosing interval i.e. tau=24 hrs. for both test and reference products and how much AUC0-24 calculation is reliable for test product?

Thanks and regards,

Edit: Full quote removed. Please see this post! [Ohlbe]

Complete thread:

UA Flag
 Admin contact
22,301 posts in 4,667 threads, 1,585 registered users;
online 10 (0 registered, 10 guests [including 7 identified bots]).
Forum time: Sunday 01:37 CEST (Europe/Vienna)

No written law has ever been more binding than
unwritten custom supported by popular opinion.    Carrie Chapman Catt

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz