Exclusion of subjects who are not in SS [Software]

posted by KR – India, 2009-04-13 14:34 (4870 d 11:02 ago) – Posting: # 3516
Views: 16,000

(edited by Ohlbe on 2009-04-13 22:30)

Dear Helmut,

Adding to that, if dosing interval for reference product is 24 hours and that of test product is 12 hours i.e. tau=24 hrs. for reference and tau=12 hrs. for test product then how can we calculate AUCtau ? means if we put tau=12 hrs. for test product in the model then which AUC area will be estimated by WinNonlin i.e first 0-12 hrs or last 0-12 hrs ?

Moreover, if we calculate AUC0-24 for both test and reference in above case then how WinNonlin calculates ? Should i give common dosing interval i.e. tau=24 hrs. for both test and reference products and how much AUC0-24 calculation is reliable for test product?

Thanks and regards,

KR
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Edit: Full quote removed. Please see this post! [Ohlbe]

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