Bioequivalence and Bioavailability Forum • F1 and F2 values and dissolution profile

F1 and F2 values and dissolution profile [Dissolution / BCS / IVIVC]

posted by drcampos – Brazil, 2009-03-04 14:51 (5912 d 20:20 ago) – Posting: # 3317
Views: 26,968
(edited on 2009-03-04 21:18)

Dear Govardhan,

First of all, I don't know of which drug you are talking about. You haven't also presented the dissolution conditions. Moreover, it's very difficult to predict the BE result from dissolution profile. I suggest you to do a pilot study (n = 8 or 12) to evalute the formulations in vivo.

Regards,

Daniel Rossi de Campos

Complete thread:

F1 and F2 values and dissolution profile govardhanpillari 2009-03-04 12:30 [Dissolution / BCS / IVIVC]
- F1 and F2 values and dissolution profiledrcampos 2009-03-04 13:51
- F1 and F2 values and dissolution profile Aceto81 2009-03-05 12:30
  - F1 and F2 values and dissolution profile Helmut 2009-03-05 14:01
  - F1 and F2 values and dissolution profile govardhanpillari 2009-03-06 06:04
    - F1 and F2 values and dissolution profile drcampos 2009-03-06 14:31
      - F1 and F2 values and dissolution profile govardhanpillari 2009-03-07 05:47
- US RLD / European reference Helmut 2009-03-05 14:15
  - European reference Ohlbe 2009-03-05 19:09
- F1 and F2 values and dissolution profile jayeshd 2010-04-17 08:58
  - EU + US Ohlbe 2010-04-17 20:19
  - F1 and F2 values and dissolution profile Dr_Dan 2010-04-19 14:51